Current controversies and challenges in allergic rhinitis management.
Identifieur interne : 002F69 ( Main/Exploration ); précédent : 002F68; suivant : 002F70Current controversies and challenges in allergic rhinitis management.
Auteurs : David Price [Singapour] ; Pete Smith [Australie] ; Peter Hellings [Belgique] ; Nikos Papadopoulos [Grèce] ; Wytske Fokkens [Pays-Bas] ; Antonella Muraro [Italie] ; Ruth Murray [Irlande (pays)] ; Alison Chisholm [Royaume-Uni] ; Pascal Demoly [France] ; Glenis Scadding [Royaume-Uni] ; Joaquim Mullol [Espagne] ; Phil Lieberman [États-Unis] ; Claus Bachert [Belgique] ; Ralph Mösges [Allemagne] ; Dermot Ryan [Royaume-Uni] ; Jean Bousquet [France]Source :
- Expert review of clinical immunology [ 1744-8409 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- immunology : Rhinitis, Allergic.
- therapy : Rhinitis, Allergic.
- Humans, Practice Guidelines as Topic, Randomized Controlled Trials as Topic.
Abstract
There are many obstacles in the path of effective allergy management, in general, and allergic rhinitis (AR) control, in particular. Chief among them are: insufficient symptom relief in some patients provided by some currently considered first-line AR treatments in real life; an over-reliance on randomized controlled trials to direct AR guideline recommendations; the need for a broader interpretation of the AR evidence base (to include randomized controlled trials and real-life studies); poorly designed and interpreted studies; and lack of an AR control concept and common language of control. These controversies are fully reviewed here and challenging solutions have been presented.
DOI: 10.1586/1744666X.2015.1081814
PubMed: 26325631
Affiliations:
- Allemagne, Australie, Belgique, Espagne, France, Grèce, Irlande (pays), Italie, Pays-Bas, Royaume-Uni, Singapour, États-Unis
- Angleterre, Attique (région), Grand Londres, Hollande-Septentrionale, Languedoc-Roussillon, Occitanie (région administrative), Écosse
- Amsterdam, Athènes, Londres, Montpellier, Édimbourg
- Université d'Édimbourg
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Le document en format XML
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xml:lang="en">Current controversies and challenges in allergic rhinitis management.</title><author><name sortKey="Price, David" sort="Price, David" uniqKey="Price D" first="David" last="Price">David Price</name><affiliation wicri:level="1"><nlm:affiliation>a 1 Research in Real Life, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>a 1 Research in Real Life, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Pete" sort="Smith, Pete" uniqKey="Smith P" first="Pete" last="Smith">Pete Smith</name><affiliation wicri:level="1"><nlm:affiliation>b 2 Department of Clinical Medicine, Griffith University, Southport, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>b 2 Department of Clinical Medicine, Griffith University, Southport</wicri:regionArea><wicri:noRegion>Southport</wicri:noRegion></affiliation></author><author><name sortKey="Hellings, Peter" sort="Hellings, Peter" uniqKey="Hellings P" first="Peter" last="Hellings">Peter Hellings</name><affiliation wicri:level="1"><nlm:affiliation>c 3 Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>c 3 Department of Otorhinolaryngology, University Hospitals Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Papadopoulos, Nikos" sort="Papadopoulos, Nikos" uniqKey="Papadopoulos N" first="Nikos" last="Papadopoulos">Nikos Papadopoulos</name><affiliation wicri:level="3"><nlm:affiliation>d 4 Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>d 4 Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Fokkens, Wytske" sort="Fokkens, Wytske" uniqKey="Fokkens W" first="Wytske" last="Fokkens">Wytske Fokkens</name><affiliation wicri:level="3"><nlm:affiliation>e 5 Department of Otorhinolaryngology, Academic Medical Center (AMC) Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>e 5 Department of Otorhinolaryngology, Academic Medical Center (AMC) Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Muraro, Antonella" sort="Muraro, Antonella" uniqKey="Muraro A" first="Antonella" last="Muraro">Antonella Muraro</name><affiliation wicri:level="1"><nlm:affiliation>f 6 Food Allergy Referral Centre, Veneto Region, Department of Women and Child Health, Padua University Hospital, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>f 6 Food Allergy Referral Centre, Veneto Region, Department of Women and Child Health, Padua University Hospital, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Ruth" sort="Murray, Ruth" uniqKey="Murray R" first="Ruth" last="Murray">Ruth Murray</name><affiliation wicri:level="1"><nlm:affiliation>g 7 Medscript (Scientific & Medical Affairs), Dundalk, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>g 7 Medscript (Scientific & Medical Affairs), Dundalk</wicri:regionArea><wicri:noRegion>Dundalk</wicri:noRegion></affiliation></author><author><name sortKey="Chisholm, Alison" sort="Chisholm, Alison" uniqKey="Chisholm A" first="Alison" last="Chisholm">Alison Chisholm</name><affiliation wicri:level="1"><nlm:affiliation>h 8 Respiratory Effectiveness Group, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>h 8 Respiratory Effectiveness Group, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Demoly, Pascal" sort="Demoly, Pascal" uniqKey="Demoly P" first="Pascal" last="Demoly">Pascal Demoly</name><affiliation wicri:level="1"><nlm:affiliation>i 9 Department of Pulmonology - Division of Allergy, University Hospital of Montpellier, Hôpital Arnaud de Villeneuve, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>i 9 Department of Pulmonology - Division of Allergy, University Hospital of Montpellier, Hôpital Arnaud de Villeneuve</wicri:regionArea><wicri:noRegion>Hôpital Arnaud de Villeneuve</wicri:noRegion><wicri:noRegion>Hôpital Arnaud de Villeneuve</wicri:noRegion></affiliation></author><author><name sortKey="Scadding, Glenis" sort="Scadding, Glenis" uniqKey="Scadding G" first="Glenis" last="Scadding">Glenis Scadding</name><affiliation wicri:level="3"><nlm:affiliation>j 10 RNTNE Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>j 10 RNTNE Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mullol, Joaquim" sort="Mullol, Joaquim" uniqKey="Mullol J" first="Joaquim" last="Mullol">Joaquim Mullol</name><affiliation wicri:level="1"><nlm:affiliation>k 11 Hospital Clinic, IDIBAPS, CIBERES, Barcelona, Catalonia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>k 11 Hospital Clinic, IDIBAPS, CIBERES, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Lieberman, Phil" sort="Lieberman, Phil" uniqKey="Lieberman P" first="Phil" last="Lieberman">Phil Lieberman</name><affiliation wicri:level="1"><nlm:affiliation>l 12 University of Tennessee College of Medicine, Memphis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>l 12 University of Tennessee College of Medicine, Memphis</wicri:regionArea><wicri:noRegion>Memphis</wicri:noRegion></affiliation></author><author><name sortKey="Bachert, Claus" sort="Bachert, Claus" uniqKey="Bachert C" first="Claus" last="Bachert">Claus Bachert</name><affiliation wicri:level="1"><nlm:affiliation>m 13 Upper Airways Research Laboratory (URL), University Hospital Ghent, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>m 13 Upper Airways Research Laboratory (URL), University Hospital Ghent, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Mosges, Ralph" sort="Mosges, Ralph" uniqKey="Mosges R" first="Ralph" last="Mösges">Ralph Mösges</name><affiliation wicri:level="1"><nlm:affiliation>n 14 Institute of Medical Statistics, Informatics, and Epidemiology, Medical Faculty, University of Köln, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>n 14 Institute of Medical Statistics, Informatics, and Epidemiology, Medical Faculty, University of Köln, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Ryan, Dermot" sort="Ryan, Dermot" uniqKey="Ryan D" first="Dermot" last="Ryan">Dermot Ryan</name><affiliation wicri:level="4"><nlm:affiliation>o 15 University of Edinburgh, Edinburgh, UK and Optimum Patient Care, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>o 15 University of Edinburgh, Edinburgh, UK and Optimum Patient Care, Cambridge</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Bousquet, Jean" sort="Bousquet, Jean" uniqKey="Bousquet J" first="Jean" last="Bousquet">Jean Bousquet</name><affiliation wicri:level="3"><nlm:affiliation>p 16 University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>p 16 University Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author></analytic><series><title level="j">Expert review of clinical immunology</title><idno type="eISSN">1744-8409</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Practice Guidelines as Topic</term><term>Randomized Controlled Trials as Topic</term><term>Rhinitis, Allergic (immunology)</term><term>Rhinitis, Allergic (therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Essais contrôlés randomisés comme sujet</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Rhinite allergique ()</term><term>Rhinite allergique (immunologie)</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Rhinite allergique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Rhinitis, Allergic</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Rhinitis, Allergic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Practice Guidelines as Topic</term><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Essais contrôlés randomisés comme sujet</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Rhinite allergique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are many obstacles in the path of effective allergy management, in general, and allergic rhinitis (AR) control, in particular. Chief among them are: insufficient symptom relief in some patients provided by some currently considered first-line AR treatments in real life; an over-reliance on randomized controlled trials to direct AR guideline recommendations; the need for a broader interpretation of the AR evidence base (to include randomized controlled trials and real-life studies); poorly designed and interpreted studies; and lack of an AR control concept and common language of control. These controversies are fully reviewed here and challenging solutions have been presented.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Irlande (pays)</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Singapour</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Écosse</li></region><settlement><li>Amsterdam</li><li>Athènes</li><li>Londres</li><li>Montpellier</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="Price, David" sort="Price, David" uniqKey="Price D" first="David" last="Price">David Price</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Smith, Pete" sort="Smith, Pete" uniqKey="Smith P" first="Pete" last="Smith">Pete Smith</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Hellings, Peter" sort="Hellings, Peter" uniqKey="Hellings P" first="Peter" last="Hellings">Peter Hellings</name></noRegion><name sortKey="Bachert, Claus" sort="Bachert, Claus" uniqKey="Bachert C" first="Claus" last="Bachert">Claus Bachert</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Papadopoulos, Nikos" sort="Papadopoulos, Nikos" uniqKey="Papadopoulos N" first="Nikos" last="Papadopoulos">Nikos Papadopoulos</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Fokkens, Wytske" sort="Fokkens, Wytske" uniqKey="Fokkens W" first="Wytske" last="Fokkens">Wytske Fokkens</name></region></country><country name="Italie"><noRegion><name sortKey="Muraro, Antonella" sort="Muraro, Antonella" uniqKey="Muraro A" first="Antonella" last="Muraro">Antonella Muraro</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="Murray, Ruth" sort="Murray, Ruth" uniqKey="Murray R" first="Ruth" last="Murray">Ruth Murray</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Chisholm, Alison" sort="Chisholm, Alison" uniqKey="Chisholm A" first="Alison" last="Chisholm">Alison Chisholm</name></noRegion><name sortKey="Ryan, Dermot" sort="Ryan, Dermot" uniqKey="Ryan D" first="Dermot" last="Ryan">Dermot Ryan</name><name sortKey="Scadding, Glenis" sort="Scadding, Glenis" uniqKey="Scadding G" first="Glenis" last="Scadding">Glenis Scadding</name></country><country name="France"><noRegion><name sortKey="Demoly, Pascal" sort="Demoly, Pascal" uniqKey="Demoly P" first="Pascal" last="Demoly">Pascal Demoly</name></noRegion><name sortKey="Bousquet, Jean" sort="Bousquet, Jean" uniqKey="Bousquet J" first="Jean" last="Bousquet">Jean Bousquet</name></country><country name="Espagne"><noRegion><name sortKey="Mullol, Joaquim" sort="Mullol, Joaquim" uniqKey="Mullol J" first="Joaquim" last="Mullol">Joaquim Mullol</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Lieberman, Phil" sort="Lieberman, Phil" uniqKey="Lieberman P" first="Phil" last="Lieberman">Phil Lieberman</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Mosges, Ralph" sort="Mosges, Ralph" uniqKey="Mosges R" first="Ralph" last="Mösges">Ralph Mösges</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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